Project title
The effect of regular alcohol consumption interacting with genetic risk factors for cardiovascular disease on the lipoprotein profile, oxidative stess and inflammation.

Project leader
Van Velden, D P

Institution
University of Stellenbosch. Department of Pathology. Faculty of Health Science.

Team members
Kotze, M J
Marnewick, J L
Blackhurst, D
Kidd, M
Nutt, L

Project description
The effect of regular alcohol consumption on the lipoprotein profile, oxidative stress status and inflammatory markers will be assessed in relation to genetic risk factors for cardiovascular disease.

The specific aims are as follows:
1.Compare the effect of moderate red wine consumption compared to brandy on the atherogenic lipoprotein profile, oxidative stress and inflammatory status.
2.Perform a genetic screen of CVD risk factors to determine individual mutation/allele frequencies in the study population
3.Correlate the presence of genetic risk factors with relevant biochemical parameters to compare gene expression in the presence and absence of known environmental triggers
4.Determine the impact of mutations/functional polymorphisms included in the genetic screen on the response to the intervention (small sample size will be a limiting factor).

Presentation(s)
1. Van Velden, D P. 2008. Response to nutrition intervention and alcohol consumption for the prevention of cardiovascular disease in patients with metabolic syndrome depends on their individual genotype. Nutrition Congress, September 2008, Pretoria, South Africa.

- Record end -